Bone Abstracts

Contents

• Opening Ceremony
• • ECTS 50th Anniversary Symposium: 50 years of research in bone and mineral metabolism
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    • 50 Years of bone imaging

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• Clinical Update
• • Clinical Update 1
  • • Osteoporosis in premenopausal women

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    • Management of osteoporosis in pre-menopausal women

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    • Genetic determinants of serum sex steroids and bone health in males

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    • Medical management of osteoporosis in men

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    • Glucocorticoid-Induced Osteoporosis

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  • Clinical Update 2
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    • Osteoporosis and fragility fractures in rheumatoid arthritis

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    • Osteoporosis in SLE

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    • Osteoporosis in ankylosing spondylitis

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    • The effect of anti-inflammatory treatments (except GC) on bone

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• Allied Health Professionals Session
• • (1)
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    • Treatment compliance in osteoporosis

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• Main Symposium
• • Developmental origins of metabolic bone disease
  • • Developmental epigenetics and the intrauterine origins of chronic disease

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    • Maternal environment and intra-uterine skeletal development

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  • Muscles and bone
  • • Skeletal muscle loss: sarcopenia and inactivity

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  • Extreme bone phenotypes
  • • Diagnosis and clinical management of genetic skeletal disorders

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  • Energy metabolism and bone
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    • Sweet bones: the effect of diabetes on bone

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  • Uncoupling of resorption and formation
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• Clinical Debate
• • (1)
  • • For the motion (ECTS)

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• Workshops
• • Fat and bone
  • • Obesity, bariatric surgery and bone

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    • Anorexia nervosa and bone

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    • Effects of fat on bone: location and age matter

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  • Developmental biology and bone
  • • Fish as a model organism for mineralization related pathologies

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  • Vertebral fractures
  • • Vertebral fracture

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    • Workshop 3: how are vertebral fractures best detected and diagnosed?

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    • Treatment of vertebral fractures

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  • Osteoclast activity and haematopoiesis
  • • The relationship between osteoclasts and haematopoiesis

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    • Are osteoclasts dispensable for haematopoietic stem cell maintenance and mobilization?

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    • Osteoclasts and hematopoietic stem cell transplantation in clinical practice

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  • Anabolic bone therapies
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    • Wnt signalling in and out of bone

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    • Therapeutic targeting of activin signaling

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  • Cancer cells and Bone
  • • How do cancer cells home to and engage in bone?

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• Meet the Professor
• • (1)
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    • Wnt and PTH signalling influences bone formation and metabolism

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    • Epigenetic regulation: what and why?

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    • Bone pain

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    • Clinical utility of bone turnover markers

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    • Assessment of therapeutic response in osteoporosis

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    • New osteoporosis treatment modalities

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    • Arthritis, inflammation and bone: from bench to bedside

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    • CRC Grants

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    • Fraud, scientific misconduct, or just an oversight?

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• Educational Symposium
• • ECTS-OARSI joint educational symposium on Osteoarthritis (Supported by Bioscientifica)
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  • Approach to the finding of abnormal laboratory results (Supported by Alexion & IDS)
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    • Low vitamin D

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• Oral Communications
• • Osteoporosis epidemiology and long term treatment complications
  • • Disease-specific perception of fracture risk and incident fracture rates among postmenopausal women: findings from the Global Longitudinal Study of Osteoporosis in Women (GLOW)

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    • Hip fractures and bone mineral density of the elderly: importance of serum 25-hydroxy vitamin D

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    • Size at birth is not associated with risk of hip fracture. results from two population-based cohorts

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    • Intake and serum levels of [alpha]-tocopherol in relation to fractures in elderly women and men

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    • Heart failure in patients treated with bisphosphonates

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    • Femur geometrical parameters in the pathogenesis of atypical femur fractures

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  • Bone quality and fracture repair - animal models
  • • Treatment with soluble activin type IIB-receptor improves bone mass and strength in a mouse model of duchenne muscular dystrophy

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    • Intermittent human parathyroid hormone (1-84) treatment improves bone mass and bone defect healing in rats with type 2 diabetes mellitus

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    • Low-magnitude high-frequency vibration improves fracture healing in aged, ovariectomized mice

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    • PPAR[beta] deficiency induces muscle and bone loss with aging but does not impair the bone biomechanical response to loading: a sarco-osteopenic mouse model

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    • Glucagon-like peptide 1 receptor is required for optimal bone strength and quality

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    • GH excess in bGH transgenic mice adversely affects bone density, architecture and quality

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  • Osteoporosis pathophysiology and genetics
  • • Heavy cannabis use negatively impacts on bone density: a population based prospective study

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    • Distinct relationships of intramuscular and subcutaneous fat with cortical bone: findings from a cross sectional study of young adult males and females

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    • Cortical exceeds trabecular bone loss before menopause but net bone loss is modest because periosteal apposition occurs

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    • Genome-wide association identifies a new susceptibility locus at 4q35 associated with clinical vertebral fractures in post-menopausal women: the GEFOS-GENOMOS consortium

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    • Causal metabolomic pathways to osteoporosis in elderly women

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  • Osteoblasts and osteocytes
  • • High-throughput DEXA and micro-CT screening in gene knockout mice identifies bone mass phenotypes

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    • The p38α MAPK pathway in osteoblasts contributes to ovariectomy-induced bone loss by upregulating interleukin 6 expression

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    • Severe osteopenia, increased bone marrow adipogenesis, and fibronectin matrix changes in mice lacking both TG2 and FXIIIA transglutaminases

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    • Glucocorticoid exposure reduces expression of sclerostin in bone marrow stromal cells

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    • Mechanical loading increases the effect of sclerostin antibody treatment in a mouse model of high turnover osteoporosis

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    • Periostin synergizes with osteocytes β-catenin to mediate the adaptive skeletal response to loading

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  • Treatment of osteoporosis
  • • A Three-year randomized sham-controlled trial of low magnitude mechanical stimulation in an elderly sample: the 'VIBES' trial

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    • Fracture risk factors during treatment with denosumab

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    • Effect of blosozumab on bone mineral density: results of a phase 2 study of postmenopausal women with low bone mineral density

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    • Effects of romosozumab administration on trabecular and cortical bone assessed with quantitative computed tomography and finite element analysis

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    • Bone anabolic efficacy and safety of ba058, a novel analog of hPTHrP: 12-month extension data from a phase 2 clinical trial in postmenopausal women with osteoporosis

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    • Testosterone replacement has a substantial benefit on bone mass, fracture incidence, libido, and sexual activities in male cardiac transplant patients: a 5-year randomized prospective controlled trial

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  • Mineralisation and energy metabolism
  • • Npp1 is a key regulator of skeletal and soft tissue mineralisation

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    • Deficiency of the bone mineralisation inhibitor NPP1 protects against obesity and diabetes

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    • Collagen XV as a bone matrix organizer

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    • Inhibition of PTH-induced vasorelaxation modulates its anabolic action

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    • A protective role for FGF23 in local defence against disrupted arterial wall integrity?

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    • An emerging role of phospho1 in the regulation of energy metabolism

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• New Investigator Workshops
• • (1)
  • • Genomics and proteomics as emerging technologies in bone research

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    • How to manage your research time and team

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    • Getting started as a post-doc

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• New Investigator Seminar
• • (1)
  • • Sclerostin/MEPE axis in OA: lessons from long bone development

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    • A GWAS in an extreme high bone mass population shows excess signal from genes associated with BMD in the normal population

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    • Bisphosphonate influence on bone quality at molecular level: study of human jaw bone sequesters by Raman microspectroscopy

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    • New PI3K[alpha]-specific inhibitor, BYL719: therapeutic interest in osteosarcoma

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    • Identification of a small molecule kinase inhibitor that enhances osteoblast differentiation of human skeletal (mesenchymal) stem cells through regulation of TGF[beta] signaling

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    • Depletion of the autophagy adaptor OPTN leads to increased osteoclast formation, fusion and survival as well as increased NF-[kappa]B activation in vitro

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    • Phenotypic dissection of bone mineral density facilitates the identification of skeletal site specificity on the genetic regulation of bone

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    • Detection of autoantibodies to osteoprotegerin in patients with rheumatoid arthritis and their association with disease activity

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• Oral Posters
• • Clinical
  • • Does vitamin D status impact on hip fracture incidence?: evidence of fracture variation with latitude and season in Sweden

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    • Meta-analysis of the effects of vitamin D supplements on bone mineral density in adults

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    • The risk of fractures in cirrhosis and chronic pancreatitis. a danish nationwide retrospective matched cohort study

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    • Relationship between bone mineral density, body composition, skin sclerosis, and serum 25(OH) vitamin D levels in systemic sclerosis

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    • Cortical and trabecular alterations in patients with bone marrow edema of the lower limb

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    • Bone marrow fat is metabolically distinct fat depot

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    • Genome-wide association study meta-analysis identifies the SOAT1/AXDND1 locus to be associated with hip and forearm fracture risk

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    • A genomic and transcriptomic approach to the high bone mass phenotype: evidences of heterogeneity and of additive effects of TWIST1, IL6R, DLX3, and PPARG

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    • Regional heterogeneity of trabecular bone microdamage density in association with trabecular microarchitecture and bone resorption in whole human lumbar vertebrae

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    • Health economic consequences of fractures in patients with osteoporosis: a national register based study of total and incremental health costs following fracture

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    • Fracture risk assessment in a primary care population: case finding using routine GP data, FRAX® And RAIDR® in the United Kingdom

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    • Hip fracture trends in Denmark 1980-2010 with age-period-cohort-effects

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    • Impact of hip fracture on mortality and life expectancy

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    • Fracture risk among men, in relation to osteopenia and osteoporosis defined by areal bone mineral density

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    • Long-term effects of symptomatic vs intensive bisphosphonate therapy for Paget's disease of bone: the PRISM-EZ study

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    • Denosumab is associated with progressive improvements in hip cortical mass and thickness

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    • Effects of odanacatib on BMD and safety in the treatment of osteoporosis in postmenopausal women previously treated with alendronate- a randomized placebo-controlled trial

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    • Effects of sclerostin antibody and maintenance of new bone induced by sclerostin antibody in animal models

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    • Resolution of effects on bone turnover markers and bone mineral density after discontinuation of long-term bisphosphonate use

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  • Pre-Clinical
  • • IGF1 regulates MC-3T3 and human primary osteoblast to osteocyte differentiation in 3D culture

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    • The effect of mTORC1 on postnatal skeletal development

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    • MEK inhibitors in fracture healing and NF1 pseudarthrosis

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    • Identification and characterization of a mesenchymal progenitor cell population involved in fracture healing

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    • Oxygen tension-mediated regulation of chondrogenic differentiation: application to stem cells based osteochondral repair

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    • Bone is the main target of activation of Canonical Wnt pathway in osteoarthritis

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    • Milk fat globule-epidermal growth factor 8 is a critical determinant of bone mass and alters the course of inflammation in arthritis

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    • Functional assessment of Paget's disease-causing mutations in sequestosome-1 (SQSTM1)

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    • miR-192 impairs invasion and tumor-induced osteolysis by repressing CCL2 in bone metastatic colonization

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    • Clusterin inhibition using OGX-011 synergistically enhances zoledronic acid activity in osteosarcoma

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    • Adipogenesis occurs at the expense of osteoblast differentiation in primary osteoblasts deficient in protease-activated receptor 2

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    • Hepatic lipase is expressed by osteoblasts and modulates bone remodeling in obesity

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    • Regulation and function of immunosuppressive molecule human leukocyte antigen G5 in human bone tissue

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    • Activation of the parathyroid hormone-receptor is involved in the pro-survival effect of hypotonic shock in osteocyte-like MLO-Y4 Cells

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    • Effects of a mutated sclerostin peptide on bone and lean mass in mice

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    • N-cadherin governs age-related osteoprogenitor cell determination in mice through modulation of Wnt5a and Wnt10b

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    • The D477N mutation in OPTN leads to increased bone turnover and enhanced osteoclast formation in Optn^D477N/D477N mice

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    • BMP-9 induces the calcification of vascular smooth muscle cells

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    • Thrombin receptor deficiency leads to osteopetrosis by decreasing the RANKL/OPG ratio

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    • Insertion of the clcn7 gene mutation pG213R in mouse induces autosomal dominant osteopetrosis type II

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• Poster Presentations
• • Clinical case posters
  • • Ten years follow up after prenatal transplantation of fetal mesenchymal stem cell in a patient with severe osteogenesis imperfecta

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    • Osteonecrosis of the jaw in a patient with rheumatoid artritis treated with an oral aminobisphosphonate: a clinical case report

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    • The possibility rule of new mutations in juvenile Paget's disease (A rare case of mild JPD)

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    • The impact of calcimimetic treatment on bone turnover in a renal patient with high turnover hyperparathyroid bone disease

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    • Late onset autosomal dominant hypophosphatemic rickets; confirmation of the diagnosis with genomic analysis

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    • Diagnosis of fibrous dysplasia with DNA tests

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    • Severe pregnancy- and lactation-associated osteoporosis: teriparatide treatment

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    • Phenotypic change in a patient with hypophosphatasia with the onset of renal failure

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    • Fibrodysplasia ossificans progressiva

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    • Hadju[ndash]Cheney syndrome: report of two cases in a family

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    • Gorham disease: a case with severe cervical spine involvement

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    • Severe osteoporosis associated with Hajdu[ndash]Cheney syndrome: follow-up after 2 years of teriparatide therapy

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  • Arthritis and other joint diseases: translational and clinical
  • • Clinical and histomorphometrical assessment of bone quality in hip osteoarthritis and osteoporosis

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    • Prophylaxis of gout flare with colchicine and vitamin C

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    • Cartilage intermediate layer protein is produced in synovial membrane of osteoarthritic joint and upregulated in osteoarthritis associated fibrosis

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    • U-C2C in estonian early knee OA cohort: progressive and non-progressive cases

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    • Bone is the main target of activation of Canonical Wnt pathway in osteoarthritis

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    • Milk fat globule-epidermal growth factor 8 is a critical determinant of bone mass and alters the course of inflammation in arthritis

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    • Vitamin K2 administration is associated with decreased disease activity in patients with rheumatoid arthritis

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    • Immunological profile of 110 rheumatoid arthritis

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    • Monosodium urate crystals inhibit tenocyte viability and function: implications for periarticular involvement in chronic gout

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    • Generalized long term bone loss in early rheumatoid arthritis in the biologic treatment era: a 10-year prospective observational study

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    • Ultrasound carotid plaque morphology in rheumatoid arthritis women without previous cardiovascular events

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    • Bone mineral density changes after total knee replacement in women over the age of 65

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    • Rehabilitation of patients with early rheumatoid arthritis, including cryotherapy, physical exercises, occupational therapy, orthoses, and therapeutic education

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    • The femoral neck fractures in patients with rheumatoid arthritis

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    • Sclerostin/MEPE axis in OA: lessons from long bone development

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    • The glutamate receptor antagonist NBQX alleviates inflammation, pathology and gait abnormalities in rat antigen induced arthritis

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    • A deletion mutation of the gene P58IPK, the cellular inhibitor of PKR and PERK, results in a degenerative joint phenotype in mice

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    • Changes and comparison of bone metabolism, bone mineral density, MRI in early rheumatoid arthritis

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  • Bone biomechanics and quality
  • • A GWAS in an extreme high bone mass population shows excess signal from genes associated with BMD in the normal population

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    • Vitamin D levels of > 85 nmol/l in the presence of adequate dietary Ca minimise bone turnover and improve bone strength

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    • Influence of the organic matrix of mineralized tissues on their dynamic mechanical properties assessed by scanning acoustic microscopy

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    • Obesity induced by a sucrose-rich diet promotes deficits in bone mineralization and microarchitecture

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    • The effect of fluoride on the DEXA score and material properties of ex vivo emu tibiae

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    • Regional heterogeneity of trabecular bone microdamage density in association with trabecular microarchitecture and bone resorption in whole human lumbar vertebrae

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    • Microarchitectural decay and microdamage accumulation in vertebral trabecular bone: a comparative analysis of the iliac crest, proximal femur, and vertebral body in the aged postmenopausal skeleton

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    • Bisphosphonate influence on bone quality at molecular level: study of human jaw bone sequesters by Raman microspectroscopy

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    • Glucose-dependent insulinotropic polypeptide receptor deletion results in a reduced bone strength and quality

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    • Prediction of vertebral body stiffness in patients with multiple myeloma using qCT-based finite element models

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    • Mechanical contrasts between osteons and interstitial bone measured by scanning acoustic microscopy

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    • Bone quality in young thalassaemic patients

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    • Protective effect of polyphenols from Aronia melanocarpa berries against cadmium-induced weakening of the femur biomechanical properties in rats

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    • 2-Oxoglutaric acid protects against side effects of maximal therapeutic doses of dexamethasone in piglets skeleton

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    • Analysis of the microarchitecutre of the human femoral head using micro-computertomography

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    • Low magnitude vibration signals attenuate the rapid bone mass induced by lipopolysaccharide

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    • Osseous alterations in condylar head after directional change of functional loading in rabbit mandibular condyle

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    • Nano-structural signs of the cortical bone fragility: atomic force microscopy study in the femoral neck of elderly hip fracture patients and healthy aged controls

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    • Nano-structural and compositional basis of devitalized tooth fragility

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    • Micro-morphological properties of osteons reveal changes in cortical bone stability during aging, osteoporosis and bisphosphonate treatment in women

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    • Microstructural adaptation of bone tissue of the facial skeleton to the distribution of occlusal load under physiological conditions

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    • Bone morphometry from human peripheral quantitative computer tomography scans is preserved by virtual high-resolution image reconstruction

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    • Strontium ranelate treatment improves bone material level properties in human transiliac bone biopsy specimens

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    • In vitro exposure of rat femur to strontium chloride influences bone material level properties and increases bone strength

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    • In vivo microindentation for the assessment of bone material level properties

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    • Quantitative assessment of bone remodelling and osteophytogenesis in murine osteoarthritis

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    • Role of receptor activity modifying protein 3 in the response of bone to mechanical loading

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    • Diagnostic discrimination of TBS and spine BMD in glucocorticoid-induced and postmenopausal osteoporosis

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  • Bone development/growth and fracture repair
  • • The effect of mTORC1 on postnatal skeletal development

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    • MEK inhibitors in fracture healing and NF1 pseudarthrosis

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    • Vascularisation and progenitor cells of primary and secondary ossification centres in the human growth plate

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    • Intermittent administration of parathyroid hormone (1[ndash]34) may induce the formation of cementum and bone: a histological study in rats

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    • Microtomography analysis of bone formation in calvarial defects filled with gelatin sponge or fibrin glue

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    • A novel biocompatible BMP6 carrier device for bone regeneration

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    • The P2Y₂ receptor restrains BMD during development

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    • Hip fracture induces a transient appearance of circulating mesenchymal stem cells

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    • Long bone phenotypic analyzes of a RANK transgenic mouse line

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    • The sealing zone is not required for mineralized cartilage resorption during endochondral ossification and growth of long bone

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    • A casein-based diet leads to a better bone status than a soy protein-based diet during moderate protein restriction in growing mice

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    • Accuracy errors in longitudinal QCT measurements of cortical thickness bone mineral density and bone mineral content using different segmentation techniques: a simulation study

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    • Calcium phosphate cement/strontium enhances bone formation in the metaphyseal osteoporotic fracture

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    • Feasibility of local CD133+ cell transplantation to avoid non-unions in biological impaired bone healing

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    • Metaphyseal fracture healing in a sheep model of low turnover osteoporosis induced by hypothalamic[ndash]pituitary disconnection

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    • Interplay of physical and biological cues in the regeneration of critical-sized bone defects

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    • The effect of post-natal (childhood) obesity on skeletal development

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    • Histologic diagnosis of aluminum osteomalacia in renal failure rats

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    • Sex-related differences of femur properties in silver foxes (Vulpes vulpes)

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    • Interrelationships between morphometric, densitometric and mechanical properties of mandible in 5-month old Polish Merino sheep

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    • Bone metabolism is influenced by serum 25-hydroxyvitamin D in healthy children

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    • Characterization of an Y1R antagonist as a drug for bone regeneration

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    • Measurement properties of radial and tibial speed of sound for screening bone health and fragility in 10[ndash]12 years old boys and girls

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    • Trabecular micro-architecture of the proximal femur during post-natal growth

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    • Variations in osteotoxic effects of cadmium on femoral bone structure after different routes of exposure

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    • The retention and bioactivity of rhBMP-2 released from a bisphosphonate-linked hyaluronan-based hydrogel

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    • The effect of incubation time of preformed injectable hydrogels on bone formation when used as carrier of rhBMP-2

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    • Premixed calcium phosphate cement as a carrier for bone morphogenetic protein 2

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    • Low calcium intake aggravates the deleterious effects of an isocaloric low protein diet on bone material level properties during growth

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    • Spirulina alga prevents impairment of peak bone mass acquisition induced by an isocaloric low protein diet

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    • The choice of fetal bovine serum influences the degree of spontaneous mineralization on silk fibroin scaffolds in 3D cell cultures

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    • Pediatric differences in bone mineral density according to ethnic background in children: the Generation R Study

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    • Identifying scoliosis in population-based cohorts: development and validation of a novel method based on total body dual energy X-ray absorptiometry scans

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    • Smaller bones at aged 10 predicts scoliosis at aged 15: results from a population-based birth cohort

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    • The healing of fracture of mandible against the chronic nitrate intoxication

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    • Osteometric parameters of mature rats mandible molars at implantation in the tibia of biogenic hydroxyapatite

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    • Macroelements composition of the dentin in rat's mandibular incisors with implanted biogenic hydroxyapatite into the tibia

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    • Organometric parameters of rat's bones under the effect of toluene vapor

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    • Identification and characterization of a mesenchymal progenitor cell population involved in fracture healing

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  • Calciotropic and phosphotropic hormones and mineral metabolism
  • • Interrelationship between osteocalcin (bgp) and energetic metabolism in two strains of rats

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    • A mixture of GOS/FOS [reg] added to a low calcium (ca) diet improved ca, phosphorus (p) and magnesium (mg) absorption: experimental model in normal growing rats

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    • Vasculature and bone: stages of atherosclerosis come along with changes in gene expression levels of calcification regulators

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    • A genetic polymorphism of osteocalcin is associated with BMI but not with parameters of glucose and lipid metabolism in women with polycystic ovary syndrome

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    • Abstract unavailable

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    • Neonatal neuroendocrine alterations impair tooth eruption, enamel mineralization, and leptin and corticosterone secretion in adulthood

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    • [alpha]2C AR KO mice present opposite bone phenotype in femur and vertebrae

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    • Bone microtomography and immunohistochemistry of acyclic rats post antiresorptive therapy and resistance training

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    • Abstract unavailable

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    • A sensitive assay for measuring circulating BMP6

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    • Biochemical bone markers of bone turnover in diabetics: a meta-analysis

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    • Short-term resveratrol supplementation stimulates serum levels of bone-specific alkaline phosphatase in obese non-diabetic men

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    • The effect of gastric bypass treatment for obesity on hormones related to bone re-modeling and intestinal growth

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    • Plasma triiodothyronine levels are positively associated with BMD and bone strength: a cross-sectional study

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    • Lower bone turnover in obesity: is there a link to energy metabolism?

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    • Pro-angiogenic and pro-survival functions of glucose in human mesenchymal stem cells upon transplantation

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    • On the importance of selenium for bone physiology

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    • Effect of high doses of vitamin D on arterial properties, adiponectin, leptin, and glucose homeostasis in type 2 diabetic patients

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    • Relationship between bone mineral density, body composition, skin sclerosis, and serum 25(OH) vitamin D levels in systemic sclerosis

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    • Role of estrogen replacement therapy in the control of immune system in postmenopausal osteoporosis

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    • Vitamin D in fragile elderly women with severe osteoporosis and uncontrolled hypertension

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    • Interaction between FGF23 R176W mutation and C716T nonsynonymous change (T239M, rs7955866) in FGF23 on the clinical phenotype in a family with autosomal dominant hypophosphatemic rickets

      ba0001pp120
    • Calcium dietary intake in southern lebanese women

      ba0001pp121
    • Effects of long-term oral administration with methimazole on femur properties in male Wistar rats

      ba0001pp122
    • Vitamin D supplementation during lactation: effect on maternal and offspring's vitamin D status and bone mass[ndash]double-blind randomized control trial

      ba0001pp123
    • Polyphenols from berries of Aronia melanocarpa improve the antioxidative capacity of the bone tissue in cadmium-exposed rats

      ba0001pp124
    • The serum serotonin and 25-OH vitamin D levels: a study in 97 menopausal women

      ba0001pp125
    • Vitamin D: light side and best time of sunshine in Riyadh, Saudi Arabia

      ba0001pp126
    • Hypercalcemia following high vitamin D loading dose

      ba0001pp127
    • Mass spectrometric immunoassay for intact parathyroid hormone: correlation with immunoassay and application to clinical samples

      ba0001pp128
    • The Ellsworth-Howard test revisited

      ba0001pp129
    • Calcium[ndash]phosphorus metabolism and calcium-regulating hormones in osteoporosis which associated with liver cirrhosis

      ba0001pp130
    • Effects of zoledronic acid on hormone levels in premenopausal women with breast cancer receiving neoadjuvant or adjuvant chemotherapy and endocrine therapy: Probone II Study

      ba0001pp131
  • Cancer and bone: basic, translational and clinical
  • • The central role of the histone demethylase JHDM1D in the regulation of tumor associated genes in bone tumor-related cells

      ba0001pp132
    • Identification of tumorigenic sarcoma cancer stem cells based on high aldehyde dehydrogenase 1 activity

      ba0001pp133
    • Isolation of ALDH1high cells by flow cytometry and investigation of the expression pattern of Wnt pathway genes in primary chordoma cell lines

      ba0001pp134
    • Anti-RANKL nanobody ALX-0141 shows sustained biomarker inhibition in a Phase I study in healthy postmenopausal Women

      ba0001pp135
    • Modulation of macrophage activation status by bisphosphonates and breast cancer cells

      ba0001pp136
    • Clusterin inhibition using OGX-011 synergistically enhances zoledronic acid activity in osteosarcoma

      ba0001pp137
    • New chondrosarcoma cell lines and mouse models to study the link between chondrogenesis and chemoresistance

      ba0001pp138
    • New PI3K[alpha]-specific inhibitor, BYL719: therapeutic interest in osteosarcoma

      ba0001pp139
    • NVP-BEZ235, a dual PI3K/mTOR inhibitor, inhibits osteosarcoma cell proliferation and the tumor development in vivo

      ba0001pp140
    • Therapeutic interest of Imatinib Mesylate in osteosarcoma

      ba0001pp141
    • Over-expression of Smad7 in osteosarcoma cells inhibits primary tumor growth, the associated bone osteolysis and the development of lung metastasis in murine xenograft model

      ba0001pp142
    • Bone remodelling in patients with an IgM monoclonal gammopathy (Waldenstrom disease [ndash] MGUS)

      ba0001pp143
    • Selective BET bromodomains epigenetic signaling inhibition as a therapeutic strategy in primary bone tumors

      ba0001pp144
    • Synergistic anti-tumour effects on human breast cancer cells by mevalonate pathway inhibitors atorvastatin and zoledronic acid

      ba0001pp145
    • Metabolomics identifies plasma biomarkers of multiple myeloma development and progression

      ba0001pp146
    • Involvement of the co-receptor RAMP2 in the progression of breast cancer-induced osteolytic lesions

      ba0001pp147
    • Direct administration of zoledronate acid improves bone structure in local osteoporotic lesion of ovariectomized rats

      ba0001pp148
    • Cytotoxicity of picocyanobacteria strains of the genera Cyanobium on osteosarcoma cells

      ba0001pp149
    • Inhibition of osteoclastogenesis by proton pump inhibitors on co-cultures of human osteoclasts and breast cancer cells

      ba0001pp150
    • Trolox inhibits breast cancer bone metastasis and bone destruction through suppression of PGE2 production

      ba0001pp151
    • Carcinoid tumors and DXA assessment: a study in 222 menopausal women

      ba0001pp152
    • The DXA results in 41 patients with neuroendocrine tumors: a transversal study

      ba0001pp153
    • miR-192 impairs invasion and tumor-induced osteolysis by repressing CCL2 in bone metastatic colonization

      ba0001pp154
    • Influence of sex steroids on sclerostin levels in patients with prostate cancer

      ba0001pp155
    • Vitamin D serum levels and breast cancer risk in a mediterranean population: a case[ndash]control study

      ba0001pp156
    • Bone metastatic prostate cancer cells regulate their growth via impairing osteoblast differentiation

      ba0001pp157
    • Role of receptor activity modifying proteins in skeletal regulation

      ba0001pp158
    • A novel antagonist of the canonical Wnt-signalling pathway, Sostdc1, is expressed in experimental models of myeloma and suppresses bone formation

      ba0001pp159
    • Glucose ceramide synthase inhibitors prevent osteoclast activation and limit myeloma-induced osteolytic lesions

      ba0001pp160
    • Effect of zoledronic acid on bone mineral density in premenopausal women receiving neoadjuvant or adjuvant therapies for breast cancer: the ProBONE II Study

      ba0001pp161
    • Effect of zoledronic acid on bone metabolism in patients with bone metastases from prostate or breast cancer: the ZOTECT Study

      ba0001pp162
  • Cell biology: osteoblasts and bone formation
  • • Hepatic lipase is expressed by osteoblasts and modulates bone remodeling in obesity

      ba0001pp163
    • Histologic evaluation of direct pulp capping by the using of calcium hydroxide and octacalcium phosphate in dental pulp of cats

      ba0001pp164
    • Implantation of octacalcium phosphate enhances alveolar ridge in rat mandible

      ba0001pp165
    • Activated protein C increases osteoblast proliferation and BMP2 induced bone formation

      ba0001pp166
    • Adipogenesis occurs at the expense of osteoblast differentiation in primary osteoblasts deficient in protease-activated receptor 2

      ba0001pp167
    • Distinct potential of osteoblast differentiation of adipose tissue- and bone marrow-derived mesenchymal stem cells

      ba0001pp168
    • Increase of mineral nodules and alkaline phosphatase levels in osteoblasts cultures by using disordered carbon nanotubes and titanium discs

      ba0001pp169
    • Calcium transport and phosphomonohydrolase activity by proteoliposomes harboring annexin V and alkaline phosphatase

      ba0001pp170
    • In vitro effect of prolactin on the osteogenic potential of bone marrow mesenchymal stem cells of rats

      ba0001pp171
    • Differential gene expression of matrix metalloproteinases (MMPs), MMP inhibitors (TIMPs and RECK), and MMP-activator (EMMPRIN/CD147) during osteogenic differentiation from human dental pulp stem cells

      ba0001pp172
    • Exogenous polyphosphate is not readily utilized for mineralization in vitro

      ba0001pp173
    • Elevated levels of serotonin decrease bone volume by direct effects on bone turnover in rats

      ba0001pp174
    • Identification of a small molecule kinase inhibitor that enhances osteoblast differentiation of human skeletal (mesenchymal) stem cells through regulation of TGF[beta] signaling

      ba0001pp175
    • The effect of fibroblast growth factor 2 on mesenchymal stromal cell differentiation

      ba0001pp176
    • Extracellular glucose alters mesenchymal stromal cell growth and differentiation

      ba0001pp177
    • Regulation and function of immunosuppressive molecule human leukocyte antigen G5 in human bone tissue

      ba0001pp178
    • Mineralizing properties of DMP1 studied in vitro with cellular and acellular 3D collagen model systems mimicking the bone tissue

      ba0001pp179
    • N-cadherin governs age-related osteoprogenitor cell determination in mice through modulation of Wnt5a and Wnt10b

      ba0001pp180
    • The impairement of bone formation and mineralization in BSP[ndash]/[ndash] mouse calvaria cell cultures is partly rescued by increasing cell density

      ba0001pp181
    • Evaluation of bone formation capacities of human adipose-derived stromal cells cultured in platelet growth factor-enriched plasma medium.

      ba0001pp182
    • Development of mice models to study implant osseointegration and failure in alveolar bone

      ba0001pp183
    • Activation of [beta]-catenin signalling enhances the osteogenic gene response to mechanical loading in mesenchymal stem cells

      ba0001pp184
    • DNA-damage, survival, differentiation, and matrix mineralization in vitro of a murine multipotent mesenchymal precursor cell line

      ba0001pp185
    • Involvement of Runx2 in the differentiation process of osteoblastic precursor cells after radiation exposure

      ba0001pp186
    • Implantation of octacalcium phosphate enhances long bone's repair in rats

      ba0001pp187
    • Intracellular calcium fluxes in human bone cells in osteoporotic and osteoarthritic patients

      ba0001pp188
    • Integrins and cadherins in mesenchymal stem cells from dental tissues: possible implication in the osteogenic differentiation process

      ba0001pp189
    • Role of vitamin D and K on human osteoblasts in vitro on primary cultures derived from osteoporotic and normal patients

      ba0001pp190
    • Nuclear translocation of oxytocin receptor mediates increased gene expression in osteoblasts

      ba0001pp191
    • Moderate hypothermia induces growth arrest in normal human osteoblast cells but retained mitochondrial metabolism in vitro

      ba0001pp192
    • Normal human osteoblast cells exerts an adaptive effect towards moderate hypothermia by retaining bone metabolism and cellular function in vitro

      ba0001pp193
    • Black tea polyphenols suppress adverse effects of TNF[alpha]-induced inflammation in osteoblast cells

      ba0001pp194
    • Microarray reveals positive effects of green and black tea polyphenols on TNF[alpha]-induced changes of gene expression

      ba0001pp195
    • The effect of enamel matrix derivative on human gingival fibroblasts cultured on zirconium disc surfaces

      ba0001pp196
    • EGF suppresses BMP2-induced osteogenic differentiation through the up-regulation of Smurf1 expression

      ba0001pp197
    • Estrogen effect on the sclerostin induction by BMP-2 in human mesenchymal stromal cells

      ba0001pp198
    • Effect of [beta]-cryptoxanthin on the differentiation of human bone-marrow stromal stem-cells treated with pioglitazone

      ba0001pp199
    • Premixed acidic calcium phosphate cement as a local delivery system for simvastatin

      ba0001pp200
    • Primary Human Bone Cells treated with Parathyroid Hormone or Dexamethasone show Effects on micro-RNA Expression Patterns Assessed by Second Generation Sequencing

      ba0001pp201
    • Expression and function of glutamate transporters in mouse primary osteoblasts

      ba0001pp202
    • Connectivity Map-based discovery of novel compounds that induce osteoblast differentiation

      ba0001pp203
    • Non-canonical BMP signaling in bone healing

      ba0001pp204
    • Thrombin receptor deficiency leads to osteopetrosis by decreasing the RANKL/OPG ratio

      ba0001pp205
    • Serum sclerostin does not reflect its expression in bone, but is related to bone mineral density

      ba0001pp206
    • In vitro 3D osteoblast-osteocyte co-culture mechanical loading model

      ba0001pp207
    • The positional origins of human osteoblasts dictate growth and differentiation potential and capacity for paracrine vascular cell cross-talk via VEGF

      ba0001pp208
    • Bone marrow stromal cells of female BAG-1 heterozygous mice exhibit reduced osteogenic potential

      ba0001pp209
    • Open source software for semi-automated histomorphometry of bone resorption and formation parameters

      ba0001pp210
    • Rab27a is involved in bone formation by osteoblasts

      ba0001pp211
    • Bone-forming cultures of rat and mouse calvarial osteoblasts: key differences in protocols

      ba0001pp212
  • Cell biology: osteoclasts and bone resorption
  • • Anti-dementia acetylcholine esterase inhibitor inhibits osteoclastogenesis

      ba0001pp213
    • Is a network of collagen fibers and blood vessels supporting pre-osteoclast trafficking from the bone marrow to the bone surface?

      ba0001pp214
    • The F-actin modulator SWAP-70 is required for proper podosome dynamics in osteoclasts

      ba0001pp215
    • Glycosaminoglycan sulfation is a key regulator of osteoclast biology and osteogenic bone cell signaling

      ba0001pp216
    • Collagen-induced arthritis reduces osteoclast differentiation potential and activity and impairs reactivity to neurotransmitter stimuli in an experimental arthritis rat model

      ba0001pp217
    • Protective effect of polyphenols from berries of Aronia melanocarpa against low exposure to cadmium-induced imbalance in the RANK/RANKL/OPG system in the bone tissue of rats

      ba0001pp218
    • Negative modulation of human osteoclastogenesis by antiepileptic drugs

      ba0001pp219
    • Modulation of osteoclastogenesis by fluoroquinolones on nano- and micro-structurated hydroxyapatite surfaces

      ba0001pp220
    • Modulation of osteoclastogenesis by antihypertensive drugs

      ba0001pp221
    • Mitogen- and stress-activated protein kinase 1 activates osteoclastogenesis in vitro and plays critical roles in bone destruction in vivo

      ba0001pp222
    • Methylation is not involved in repression of ADRA2A in osteocytes

      ba0001pp223
    • Polyunsaturated fatty acids and phytoestrogens modulate osteoclastogenesis and bone resorption in raw 264.7 macrophages

      ba0001pp224
    • Inhibition of lipopolysacharide induced osteoclast formation and bone resorption in vitro and in vivo in mice by cystatin C

      ba0001pp225
    • Regulation of osteoclastogenesis by toll-like receptor 5

      ba0001pp226
    • RANKL immobilized on [beta]-TCP induces and maintains osteoclast formation

      ba0001pp227
    • Bisphosphonates differently affect jaw and long-bone marrow cells

      ba0001pp228
    • The D477N mutation in OPTN leads to increased bone turnover and enhanced osteoclast formation in OptnD477N/D477N mice

      ba0001pp229
    • Depletion of the autophagy adaptor OPTN leads to increased osteoclast formation, fusion and survival as well as increased NF-[kappa]B activation in vitro

      ba0001pp230
    • Osteoclasts activity is affected by adenovirus infection

      ba0001pp231
    • The use of photo-activatable fluorophores to study the turnover of the receptor activator of NF[kappa]B receptor in health and disease

      ba0001pp232
    • Investigating homozygous vs heterozygous expression of disease-associated receptor activator of NF[kappa]B mutations in vitro

      ba0001pp233
    • Do ecto-nucleotidases play a role in the regulation of osteoclast function?

      ba0001pp234
    • Differential effects of nitrogen-containing bisphosphonates on human PBMCs and MUTZ-3 cells

      ba0001pp235
    • Osteoclast resorptive surface: correlation of structure and function

      ba0001pp236
  • Cell biology: osteocytes
  • • Nucleotide and mechanically induced ATP release pathways in osteocytes

      ba0001pp237
    • Calcium Sensing Receptor is expressed on/in osteocyte-like MLOY4 culture and modulated by strontium ranelate

      ba0001pp238
    • Glycosaminoglycans and their sulfate derivates differentially regulate the osteocytic phenotype of murine and rat osteocyte-like cell lines

      ba0001pp239
    • RANKL subcellular trafficking in osteocytes

      ba0001pp240
    • Inhibition of osteocyte-induced osteoclast precursor proliferation and migration by mechanical strain

      ba0001pp241
    • Activation of the parathyroid hormone-receptor is involved in the pro-survival effect of hypotonic shock in osteocyte-like MLO-Y4 Cells

      ba0001pp242
    • Single osteocyte gene expression in an in vivo model for load-induced bone adaptation

      ba0001pp243
    • Strontium ranelate and conditioned medium from mechanically-stimulated human bone cells both enhance osteogenic differentiation of mesenchymal stem cells

      ba0001pp244
    • IGF1 regulates MC-3T3 and human primary osteoblast to osteocyte differentiation in 3D culture

      ba0001pp245
    • Development of a novel 3D mineralising culture system to investigate the differentiation of osteoblasts to osteocytes

      ba0001pp246
  • Chondrocytes and cartilage
  • • Expression of novel cartilage genes during maturation of cultured chondrocytes

      ba0001pp247
    • Intracellular calcium is influenced by the nuclear magnetic resonance therapy in Cal-78 chondrosarcoma cells

      ba0001pp248
    • Impairment of endochondral ossification by Hoxa2 overexpression: a plausible molecular explanation of idiopathic proportionate short stature

      ba0001pp249
    • In vitro effects of caffeine on the proliferation, apoptosis, and gene transcripts expression of chondrogenic differentiation in growth cartilage of rats

      ba0001pp250
    • Endochondral bone growth of rats

      ba0001pp251
    • Modulation of c-Myb during chondrogenesis

      ba0001pp252
    • Can adrenomedullin be a potential osteoarthritis treatment?

      ba0001pp253
    • Oxygen tension-mediated regulation of chondrogenic differentiation: application to stem cells based osteochondral repair

      ba0001pp254
    • Effects of an in vitro low-oxygen-tension preconditioning of adipose stem cells on their in vivo chondrogenic potential: application in cartilage tissue repair

      ba0001pp255
    • Sclerostin preserves chondrocyte maintenance by modulating the crosstalk between canonical and non-canonical Wnt pathways

      ba0001pp256
    • Stress-induced matrix metalloproteinase production in cartilage does not depend on NALP3-inflammasome in osteoarthritis

      ba0001pp257
    • Transcription factor Nkx3.2 plays crucial role in primary chondrogenesis by up-regulating type II collagen a1 transcription activity

      ba0001pp258
    • The influence of 2-oxoglutaric acid on articular cartilage of gastrectomised rats

      ba0001pp259
    • Dietary 2-oxoglutarate protects femoral cartilage of 9 months male pigs prenatally treated with dexamethasone

      ba0001pp260
    • Prenatally administered acrylamide programs a gut-bone axis of guinea pig newborns

      ba0001pp261
    • Establishing an in vitro system to study chondrocyte phenotypes associated to human hereditary hemochromatosis and identify molecular players involved in chondrocyte related iron metabolism

      ba0001pp262
    • Inflammatory effects on knee joint tissue by indoxyl sulfate

      ba0001pp263
    • Upregulation of GAP-43 is linked to the cartilage repair by microarray analysis

      ba0001pp264
    • Decrypting TGF[beta] signaling in age-induced osteoarthritis

      ba0001pp265
    • The Rho/ROCK GTPase pathway differentially modulates chondrocyte and osteoblast differentiation from pluripotent stem cells

      ba0001pp266
  • Genetics
  • • A genetic determinant of vitamin D and its role in prostate cancer

      ba0001pp267
    • No mutations in the serotonin related TPH1 and HTR1B genes in patients with monogenic sclerosing bone disorders

      ba0001pp268
    • Expression analysis of mesenchymal KS483 cells during differentiation towards osteoblasts

      ba0001pp269
    • SQSTM1/P392L post-zygotic mutations in unrelated patients with Paget's disease of bone

      ba0001pp270
    • A familial case of osteogenesis imperfecta: study of genotype-phenotype correlation.

      ba0001pp271
    • Comparison of gene expression in osteoblasts from patients of Polynesian and Caucasian ethnicities

      ba0001pp272
    • Functional analysis of the two Runx3 promoters in osseous and non-osseous cells: implications for tissue/differentiation specific transcription of distinct isoforms

      ba0001pp273
    • Association between polymorphisms in leptin, its receptor and [beta] adrenergic receptors genes and bone mineral density in postmenopausal Korean women

      ba0001pp274
    • Genetic aspects of bone remodeling disturbance in patients with aggressive periodontitis

      ba0001pp275
    • No association between the CYP1B1/Leu432Val polymorphism and osteoporosis-related traits in Slovak postmenopausal women

      ba0001pp276
    • A genomic and transcriptomic approach to the high bone mass phenotype: evidences of heterogeneity and of additive effects of TWIST1, IL6R, DLX3, and PPARG

      ba0001pp277
    • Gene-wide association study of RANK and RANKL genes in the bone context: functional study of BMD-associated SNPs

      ba0001pp278
    • Genome-wide association study meta-analysis identifies the SOAT1/AXDND1 locus to be associated with hip and forearm fracture risk

      ba0001pp279
    • Association between dentinogenesis imperfecta and mutations in COLIA1 and COLIA2 genes

      ba0001pp280
    • Role of the functional Toll-like receptor-3 promoter polymorphism in the increased risk of osteoarthritis

      ba0001pp281
    • Phenotypic dissection of bone mineral density facilitates the identification of skeletal site specificity on the genetic regulation of bone

      ba0001pp282
    • Discovery and replication of several loci significantly associated with lean body mass: a large meta-analysis of genome wide association studies (GWAS) from the 'charge' and 'gefos' consortia

      ba0001pp283
  • Muscle, physical activity and bone
  • • Raising CK: what it means according to different clinical landscape?

      ba0001pp284
    • Prolonged botulinum toxin type A-induced muscle paralysis results in loss of bone mineral density and bone strength in young female rats

      ba0001pp285
    • Muscle function and quality of life in primary hyperparathyroidism

      ba0001pp286
    • Muscle strength and peripheral fractures in osteoporotic patients

      ba0001pp287
    • Microgravity modulates nitric oxide homeostasis in vascular system

      ba0001pp288
    • The outcomes and costs of falls in elderly women

      ba0001pp289
    • Response of mechanically strained tenocytes to different cell culture substrates

      ba0001pp290
    • Physical activity, bone metabolism and inflammatory markers, and bone mineral density in elderly men: a preliminary investigation

      ba0001pp291
    • Sex-specific association of physical activity with bone mass distribution at the femoral neck and trochanter in young adults

      ba0001pp292
    • Sarcopenia in patients with spondyloarthritis: is there any relation with radiological damage?

      ba0001pp293
    • Influence of mechanical loading and skeleton geometry in bone mass at the proximal femur in 10[ndash]12 years old children: a longitudinal study

      ba0001pp294
    • Proximal femur geometry as moderator factor for the effect of mechanical loading during gait: a bone remodeling analysis

      ba0001pp295
    • Body composition relationship in Korean old people

      ba0001pp296
    • Prevalence of sarcopenia and its association with osteporosis in Korean postmenopausal women

      ba0001pp297
    • The effects of vitamin D supplementation and fitness program for biochemistry, muscle mass and physical functions in elderly women

      ba0001pp298
    • Influence of gym high-intensity dynamic exercises and therapeutic exercises on functional status of patients with early rheumatoid arthritis

      ba0001pp299
    • Vitamin D deficiency is associated with nonspecific skeletal pain in Saudi women

      ba0001pp300
    • Effect of vitamin D status on muscle function and physical performance among saudi postmenopausal women: a cross-sectional study

      ba0001pp301
    • Morphology of muscle attachment sites and microarhitecture of underlying bone as the markers of physical activities of past populations

      ba0001pp302
    • The effect of different exercise modes on bone density in middle-aged and older men: a systematic review

      ba0001pp303
    • Everyday activity, important factors and quality of life in children and youths with osteogenesis imperfecta

      ba0001pp304
    • Associations of 25-hydroxyvitamin D concentrations with quality of life and self-rated health

      ba0001pp305
    • Increased activity associated with exercise does not rescue aged bone's impaired response to local mechanical loading

      ba0001pp306
    • Muscle power and force may influence cortical bone strength via distinct mechanisms: findings from a cross sectional study of high bone mass cases and controls

      ba0001pp307
    • Sarcopenia in Ukrainian women of different age

      ba0001pp308
    • Lean mass, not obesity, is related to total body bone mineral content in boys

      ba0001pp309
  • Osteoporosis: evaluation and imaging
  • • Osteoporosis and osteopenia of the spine in rheumatic patients, treated with glucocorticosteroids

      ba0001pp310
    • Appropriate osteoporosis treatment by family physicians in response to FRAX vs caroc reporting: a randomized controlled trial

      ba0001pp311
    • Correlation of bioelectrical impendance analysis and dual energy X-ray absorptiometry for bone mineral content and bone mineral density in young healthy humans

      ba0001pp312
    • Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis

      ba0001pp313
    • Communication of fracture risk and treatment benefit in terms of 'bone health age' using FRAX or Qfracture

      ba0001pp314
    • The stability of intact parathyroid hormone in human blood during different sampling conditions and long-term storage in serum tubes

      ba0001pp315
    • Cortical and trabecular bone parameters from HR-Pqct images at the Tibia: a local comparison with synchrotron radiation micro-computed tomography

      ba0001pp316
    • A 3D QCT technique of the thoracic and lumbar spine: integral volume and intervertebral disc space increase and bmd decreases from T6 to L4

      ba0001pp317
    • Binding kinetics of fluorescent bisphosphonates as a tool for monitoring bone dynamics in vivo

      ba0001pp318
    • Prevalence of FRAX clinical risk factors: dietary calcium intake habits and osteoporosis screening in Greek women

      ba0001pp319
    • Quantitative ultrasound of os calcis BMD vs conventional DXA and peripheral QCT in interval assessment of BMD changes in adolescent females

      ba0001pp320
    • Use of os calcis quantitative ultrasound for bone mineral density screening in adolescents with menstrual dysfunction

      ba0001pp321
    • Comparative assessment of bone mineral density of the femoral neck between dual-energy X-ray absorptiometry and a new ultrasonic method

      ba0001pp322
    • A new ultrasonic method for diagnosis of osteoporosis on hip and spine

      ba0001pp323
    • Strong diagnostic agreement between a novel ultrasound-based method for lumbar densitometry and dual-energy X-ray absorptiometry

      ba0001pp324
    • Relationship between quantitative ultrasound parameters at calcaneous and health-related quality of life domains in postmenopausal Italian women: the FEDRO study

      ba0001pp325
    • FRAXture:- does FRAX reflect the risk of fracture in real practice?

      ba0001pp326
    • BMA assessment standard curves for wrist and ankle of both sexes: data from EpiReumaPt

      ba0001pp327
    • Bone mineral density distribution in early osteoporotic bone

      ba0001pp328
    • Discordance of Z-score in healthy premenopausal women with BMD below the expected range of age and contributing factors: the Korea national health and nutrition examination survey 2008[ndash]2009

      ba0001pp329
    • Factors that affects on bone density in premenopausal women

      ba0001pp330
    • May we screen with FRAX clinical factors?

      ba0001pp331
    • Osteoporosis and bone fractures in elder women with rheumatoid arthritis

      ba0001pp332
    • Calcification of the coronary arteries among the males with coronary heart disease and osteoporosis

      ba0001pp333
    • Bone fragility in patients with alcoholic liver cirrhosis: can hip structure analysis better predict risk of hip fracture

      ba0001pp334
    • Usefulness of bone turnover markers in the evaluation of fracture risk in type 2 diabetes

      ba0001pp335
    • TBS improves the detection of subjects at risk of fracture irrespectively to the BMD status: a Spanish population-based study

      ba0001pp336
    • Dietary calcium and vitamin D intake and serum 25-hydroxyvitamin D and parathyroid hormone levels in healthy elderly Spanish men: the relationship with calcaneal and phalangeal quantitative ultrasound and phalangeal dual energy X-ray absorptiometry

      ba0001pp337
    • Low testosterone levels are associated with poor peripheral bone mineral density and quantitative bone ultrasound at phalanges and calcaneus in healthy elderly men

      ba0001pp338
    • What is the performance in vertebral fracture discrimination by bone mineral density, micro-architecture estimation, and FRAX in stand-alone, combined or adjusted approaches: the OsteoLaus Study

      ba0001pp339
    • Trabecular bone score and bone mineral density of lumbar spine in healthy women: pros and cons

      ba0001pp340
  • Osteoporosis: pathophysiology and epidemiology
  • • Vitamin D levels in immobilized Spanish adults: the Camargo Cohort Study

      ba0001pp341
    • Bone mineral density in statin users: analysis of a population-based cohort from Spain

      ba0001pp342
    • Fracture risk among men, in relation to osteopenia and osteoporosis defined by areal bone mineral density

      ba0001pp343
    • Bone turnover markers in old old vs postmenopausal women

      ba0001pp344
    • Mortality after osteoporosis-related hip fractures in Austria 2008[ndash]2010

      ba0001pp345
    • Association of osteoprotegerin gene polymorphisms with bone mineral density and bone turnover markers in postmenopausal women and elderly men

      ba0001pp346
    • Acute effects of glucocorticoids on CRP and bone markers

      ba0001pp347
    • Variation in osteoporosis patients' service utilization in general practice clinics

      ba0001pp348
    • Women with hormone sensitive breast cancer who have received chemotherapy including prednisolone have reduced bone mass

      ba0001pp349
    • The risk of fractures in cirrhosis and chronic pancreatitis. a danish nationwide retrospective matched cohort study

      ba0001pp350
    • Cytokine levels in the bone marrow are not just a reflection of the levels in serum: suggesting that bone marrow constitutes an independent compartment

      ba0001pp351
    • The relationship between urban[ndash]rural migration and bone mineral density in an urban[ndash]rural adult population: cross sectional findings from the hyderabad indian migration study

      ba0001pp352
    • Apolipoprotein-E deficiency prevents obesity but predisposes to the development of osteoporosis following long-term exposure to Western-type diet, in mice

      ba0001pp353
    • Apolipoprotein A-I deficiency is associated with decreased expression of osteoblast-specific regulators in mice

      ba0001pp354
    • Diabetes and obesity as independent risk factors for osteoporosis in postmenopausal women: a population study of 3354 people: first results of the PROF Project (Prevention of Osteoporosis and Fractures)

      ba0001pp355
    • Microgravity-induced osteoporosis: a challenge for the future of space programs

      ba0001pp356
    • The prevalence of osteoporosis and risk factors for bone demineralization in Italy: first results from the firmo study

      ba0001pp357
    • Osteoporosis and 'fragility fractures' in 110 centenarians living at the nursing home of Milan

      ba0001pp358
    • Ten years of increasing hip fractures incidence in Italy but first good news from the Analysis of National Hospitalizations Records 2000[ndash]2009

      ba0001pp359
    • Osteoporosis risk factor correlation with BMD in Latvia

      ba0001pp360
    • Referral rate of Lebanese males for osteodensitometry

      ba0001pp361
    • Assessment of osteoporosis knowledge among Lebanese physicians

      ba0001pp362
    • Adolescents' lifestyle and bone health: what about the young bones in Norway?

      ba0001pp363
    • Osteoporosis an independent predictor of mortality in hip fracture patients

      ba0001pp364
    • Effect of sitagliptin on bone growth and remodeling in non-ovariectomized and ovariectomized rats

      ba0001pp365
    • Caffeine at a moderate dose favorably affected bone mechanical properties in ovariectomized rats

      ba0001pp366
    • Estimated glomerular filtration rate is associated with bone fragility in the elderly

      ba0001pp367
    • Portuguese and spanish FRAX[reg] tool versions: a comparative analysis from EpiReumaPt

      ba0001pp368
    • Changes in bone mineral density of the both proximal femur after total knee arthroplasty

      ba0001pp369
    • Up-regulation of inhibitors of DNA binding/differentiation gene during alendronate-induced osteoblast differentiation

      ba0001pp370
    • Comparative analysis of vitamin D level with or without osteoporotic spinal compression fracture in Korean elderly patients

      ba0001pp371
    • Decreased bone mineral density is associated with coronary atherosclerosis in healthy postmenopausal women

      ba0001pp372
    • Prevalence of vitamin D deficiency and low bone mineral density in healthy Saudi women

      ba0001pp373
    • Effect of two types of bariatric surgery (gastrojejunal bypass and sleeve gastroplasty) on gene expression of bone remodeling markers in Goto-Kakizaki rats

      ba0001pp374
    • 25-Hydroxyvitamin D values in liver transplant candidates

      ba0001pp375
    • Ursodeoxycholic acid protects osteoblastic cells from bilirubin and lithocholic acid induced apoptosis

      ba0001pp376
    • Effect of glucocorticoid treatment on Wnt signalling antagonists (sclerostin and Dkk-1) and their relationship to bone turnover and bone mass

      ba0001pp377
    • Role of Wnt antagonists (sclerostin and Dkk-1) on bone turnover markers and bone mass, in patients with complete spinal cord injury: preliminary results

      ba0001pp378
    • Where and when do hip fractures occur? A population-based study

      ba0001pp379
    • Hip fracture trends in Denmark 1980[ndash]2010 with age-period-cohort-effects

      ba0001pp380
    • Impact of hip fracture on mortality and life expectancy

      ba0001pp381
    • The relationship between cardiovascular risk and bone mineral density: an important role for anthropometry

      ba0001pp382
    • Detection of autoantibodies to osteoprotegerin in patients with rheumatoid arthritis and their association with disease activity

      ba0001pp383
    • Does vitamin D status impact on hip fracture incidence?: evidence of fracture variation with latitude and season in Sweden

      ba0001pp384
    • Fracture risk assessment in a primary care population: case finding using routine GP data, FRAX[reg] And RAIDR[reg] in the United Kingdom

      ba0001pp385
    • Effect of thymogen injections on dentinogenesis in mandibular incisors after thymectomy

      ba0001pp386
    • Sclerostin associated with vertebral bone marrow fat in older men but not women

      ba0001pp387
    • The association of leptin: adiponectin ratio with bone in overweight and obese postmenopausal women

      ba0001pp388
    • Serum leptin and adiponectin in overweight and obese postmenopausal women after the 6-month weight loss program and their relationship with BMD

      ba0001pp389
  • Osteoporosis: treatment
  • • Abstract unavailable

      ba0001pp390
    • Electronic clinical decision support for the management of osteoporosis in primary care

      ba0001pp391
    • Anti-osteoporosis treatment amongst austrian hip fracture patients: status quo, and effects on mortality and subsequent fracture risk

      ba0001pp392
    • Remarkable bone mineral density increases on teriparatide in patients with glucocorticoid-induced osteoporosis and Crohn's disease

      ba0001pp393
    • Effects of a new conjugate drug in a rat model of postmenopausal osteoporosis

      ba0001pp394
    • Renal function and safety result after 1 year treatment of zoledronic acid in Chinese women with postmenopausal osteoporosis

      ba0001pp395
    • Characterization and risk factors of acute-phase response following a first-dose administration of zoledronic acid for treatment of osteoporosis

      ba0001pp396
    • Intact heparin inhibits BMP6 osteogenic activity

      ba0001pp397
    • Health economic consequences of fractures in patients with osteoporosis: a national register based study of total and incremental health costs following fracture

      ba0001pp398
    • Assessment of serum 25-hydroxyvitamin D concentrations in postmenopausal osteoporotic women: a retrospective study to evaluate long-term treatment with vitamin D3

      ba0001pp399
    • Osteonecrosis of the jaw and non-malignant disease

      ba0001pp400
    • Effectiveness of Strontium Renalate therapy for osteoporosis in men

      ba0001pp401
    • Do Bisphosphonates remain basic drugs for the treatment of osteoporosis?

      ba0001pp402
    • Parathyroid hormone changes following denosumab treatment in postmenopausal osteoporosis

      ba0001pp403
    • Sequential therapy after PTH 1[ndash]84 treatment: comparison among bisphosphonates and strontium ranelate

      ba0001pp404
    • Adherence to therapy: outcomes after seven years of treatment with bisphosphonates

      ba0001pp405
    • In real clinical practice osteoporosis drugs are taken for a very short period: analysis of persistence in the campania region

      ba0001pp406
    • Effect of a mixture of calcium, vitamin D, inulin and soy isoflavones on bone metabolism in post-menopausal women: a retrospective analysis

      ba0001pp407
    • Vertebroplasty vs kyphoplasty in osteoporotic vertebral fractures: a finite element comparative analysis

      ba0001pp408
    • 25-OH vitamin D and [gamma]-[delta] TCR lymphocyte interplay in the pathogenesis of acute phase reaction after zoledronic acid infusion for osteoporosis treatment

      ba0001pp409
    • Bone turnover markers and radiographic progression of vertebral compression fractures during anti-osteoporotic therapy

      ba0001pp410
    • Changes in low back pain and upper gastrointestinal symptoms in Japanese osteoporotic patients after switching to once-monthly oral minodronate from daily or weekly bisphosphonates

      ba0001pp411
    • Preoperative bisphosphonate treatment in patients with neuromuscular scoliosis improves bone strength of vertebral body

      ba0001pp412
    • Early response to once-monthly oral minodronate after switching from daily or weekly bisphosphonates in Japanese osteoporotic patients

      ba0001pp413
    • Treatment with eldecalcitol (ED-71) and raloxifene combined increases cancellous and cortical bone strength in ovariectomized rats

      ba0001pp414
    • Patient preference and adherence to once-monthly oral minodronate in Japanese osteoporotic patients previously using daily or weekly bisphosphonates

      ba0001pp415
    • Meta-analysis of the effects of vitamin D supplements on bone mineral density in adults

      ba0001pp416
    • A case of atypical femoral fracture with abnormal cortical bone characterized by impaired mineralization and pyrophosphate accumulation

      ba0001pp417
    • Myricetin suppress LPS-induced MMP expression in human periodontal ligament fibroblasts and inhibit osteoclastogenesis by downregulating NFATc1 in LPS-induced RAW 264.7 cells

      ba0001pp418
    • Analysis of clinical assessment and efficacy of once-yearly i.v. zoledronic acid for osteoporosis

      ba0001pp419
    • Subsequent hip fracture in Inchon and Bucheon area of Korea (Cohort study)

      ba0001pp420
    • The efficiency of bisphosphonates (alendronate, risedronate, ibandronate) for postmenopausal osteoporosis after 1 year of therapy

      ba0001pp421
    • Bisphosphonates poisonous action

      ba0001pp422
    • Three years' experience of zoledronic acid use in the treatment of postmenopausal osteoporosis

      ba0001pp423
    • Acute phase response and zoledronic acid therapy

      ba0001pp424
    • Evaluation with densitometry of patients with breast cancer and low bone mineral density after 2 years of treatment

      ba0001pp425
    • Characterization and incidence on acute phase reaction in Paget's disease after zoledronic acid infusion

      ba0001pp426
    • Risk factors for the development of vertebral fractures after percutaneous vertebroplasty

      ba0001pp427
    • Persistence with different anti-osteoporosis medications: a population-based cohort study.

      ba0001pp428
    • Study description and baseline characteristics of the population enrolled in the extended forsteo[reg] observational study (ExFOS)

      ba0001pp429
    • First in man study of a novel and highly selective cathepsin K inhibitor miv-711 [ndash] safety, pharmacokinetics and pharmacodynamics of single ascending oral doses in healthy subjects

      ba0001pp430
    • Bisphosphonate treatment of painful vertebral fractures due to osteoporosis in five boys with Duchenne muscular dystrophy

      ba0001pp431
    • Effects of a mutated sclerostin peptide on bone and lean mass in mice

      ba0001pp432
    • Denosumab is associated with progressive improvements in hip cortical mass and thickness

      ba0001pp433
    • Bone histology and histomorphometry: effects of 5 years of denosumab in the FREEDOM Extension

      ba0001pp434
    • Denosumab's dynamic CTX profile is maintained over 6 years of treatment: first 3 years of the FREEDOM extension study

      ba0001pp435
    • Bone mineral density changes in patients with prior fracture suboptimally treated with a bisphosphonate: results from denosumab (DMAb)/ibandronate and DMAb/risedronate trials

      ba0001pp436
    • The spatial relationship between bone formation and bone resorption in healthy and ovariectomized mice treated with PTH, bisphosphonate or mechanical loading

      ba0001pp437
    • Optimizing fracture prevention: the fracture liaison service, an observational study

      ba0001pp438
    • The direct and indirect costs of an osteoporotic fracture: a prospective evaluation of elderly patients with a clinical fracture

      ba0001pp439
    • Strontium potently inhibits mineralisation in bone-forming osteoblast cultures while osteoclast formation from marrow mononuclear cells is moderately reduced

      ba0001pp440
    • Reducing the risk of hypocalcaemia with parenteral antiresorptive therapies: an audit

      ba0001pp441
    • Design of a prospective observational study to evaluate persistence and adherence during denosumab treatment, and patient characteristics in postmenopausal women with osteoporosis in routine clinical practice

      ba0001pp442
    • Zoledronic acid vs alendronate in the management of osteoporosis

      ba0001pp443
    • Correction of vitamin D deficiency in women with postmenopausal osteoporosis

      ba0001pp444
    • Effectiveness of the active metabolite of vitamin D in the treatment of postmenopausal osteoporosis

      ba0001pp445
    • Effects of odanacatib on BMD and safety in the treatment of osteoporosis in postmenopausal women previously treated with alendronate[ndash] a randomized placebo-controlled trial

      ba0001pp446
    • Effects of sclerostin antibody and maintenance of new bone induced by sclerostin antibody in animal models

      ba0001pp447
    • Resolution of effects on bone turnover markers and bone mineral density after discontinuation of long-term bisphosphonate use

      ba0001pp448
    • Odanacatib treatment reduces remodeling- and stimulates modeling-based bone formation in adult OVX monkeys

      ba0001pp449
    • Transdermal delivery of BA058, a novel analog of hPTHrP (1-34), with a short wear time patch in preclinical and clinical studies

      ba0001pp450
    • Estimation of vertebral and femoral strength during the first three years of denosumab therapy using an alternative smooth non-linear finite element methodology

      ba0001pp451
    • Curbing our enthusiasm when prescribing strenuous exercises in osteopenia/osteoporosis, when fracture may occur under good intensions

      ba0001pp452
    • Factors influencing levels of bone resorption during denosumab dosing

      ba0001pp453
  • Other diseases of bone and mineral metabolism
  • • Long bone fragility in NF1 is due to deficiency of architecture, micro-structure and matrix mineralization

      ba0001pp454
    • Cortical and trabecular alterations in patients with bone marrow edema of the lower limb

      ba0001pp455
    • Altered bone material properties in HLA-B27 rats, an animal model for arthritis, ankylosing spondylitis, and gastrointestinal inflammation

      ba0001pp456
    • DPP4 inhibition attenuates bone loss in diabetic rats

      ba0001pp457
    • Evaluation of bone and mineral metabolism in patients with the syndrome of resistance to thyroid hormone

      ba0001pp458
    • Correlates of tissue mineral density of bone samples from total hip arthroplasty patients with type 2 diabetes: an ex vivo study

      ba0001pp459
    • Osteopontin ASARM peptide binding to crystal faces of hydroxyapatite [ndash] computational simulations

      ba0001pp460
    • QTc interval in hypercalcemic kidney transplant recipients

      ba0001pp461
    • Expression of RANKL/RANK/OPG in colon during experimental inflammatory bowel disease

      ba0001pp462
    • Bone morphogenetic protein-7 reduces kidney cold ischemic injury by maintaining epithelial phenotype of tubular cells

      ba0001pp463
    • Effects of add-on parathyroid hormone (PTH(1-84)) substitution therapy in hypoparathyroidism: results from 2.5 years of PTH treatment

      ba0001pp464
    • Post surgical hypoparathyroidism and the risk of fractures

      ba0001pp465
    • Bone cross-sectional geometry in adult patients with hypophosphatemic rickets: a hip structural analysis study

      ba0001pp466
    • Bone marrow fat is metabolically distinct fat depot

      ba0001pp467
    • Miglustat therapy normalizes bone mass in a mouse model of cystic fibrosis

      ba0001pp468
    • MEPE-derived ASARM peptide impairs mineralization in tooth models of X-linked hypophosphatemia

      ba0001pp469
    • Determinants of bone loss in cystic fibrosis

      ba0001pp470
    • Long-term energy deficiency in mice induces bone alterations reversed by long-term recovery

      ba0001pp471
    • Monocytic expression of osteoclast-associated receptor is induced in atherosclerotic mice and regulated by oxidized low-density lipoprotein in vitro

      ba0001pp472
    • Evidence of increased bone resorption in early post menopausal women with idiopathic hypercalciuria: study with biochemical markers and pQCT of the Tibia

      ba0001pp473
    • Insertion of the clcn7 gene mutation pG213R in mouse induces autosomal dominant osteopetrosis type II

      ba0001pp474
    • Multidisciplinary studies of ancient calcified tissues: renal stones from mummies

      ba0001pp475
    • multidisciplinary studies of ancient calcified tissues II: contents from Egyptian canopic jars

      ba0001pp476
    • A OPTN variant (rs1561570) interacts with TNFRSF11A polymorphism (rs1805034) on the clinical phenotype of sporadic Paget's disease of bone

      ba0001pp477
    • Circulating sclerostin level in patients with ossification of the posterior longitudinal ligament of the spine

      ba0001pp478
    • The activation of RANK/RANKL/OPG system in normal pregnancy and pre-eclampsia

      ba0001pp479
    • Effect of polyphenolic compounds from Aronia melanocarpa berries on cadmium accumulation in the bone tissue

      ba0001pp480
    • Single nucleotide polymorphisms identification and functional analysis in PDB6 locus: a target locus for Paget's disease of bone

      ba0001pp481
    • Zoledronate efficacy and safety in active Paget's disease: long-term follow-up and retreatment in clinical practice

      ba0001pp482
    • Did Paget's bone disease changed over the last decade?

      ba0001pp483
    • Osteocyte metabolism on post-menopausal bone loss and role of hormone replacement therapy

      ba0001pp484
    • The effect of hormone therapy on the change of bone mineral density in women with early menopause from pelvic radiation therapy for uterine cervical cancer

      ba0001pp485
    • The relationship between renal function, bone mineral density and arterial stiffness in healthy postmenopausal women.

      ba0001pp486
    • Preliminary study for the effect of PDGF or mesenchymal stem cells on tissue repair of cutaneous radiation injury

      ba0001pp487
    • Circulating RANKL is not a reliable biomarker for bone loss in primary hyperparathyroidism

      ba0001pp488
    • Homeostasis of calcium and vitamin D in patients with aggressive periodontitis

      ba0001pp489
    • Fracture predictors in patients with endogenous cortisol excess

      ba0001pp490
    • Cross sectional study of bone mass and 25OH vitamin D levels in erythropoietic protoporphyria

      ba0001pp491
    • Allele dependent silencing of collagen type I using small interfering RNAs targeting 3[prime]UTR indels [ndash] a novel therapeutic approach in osteogenesis imperfecta

      ba0001pp492
    • Functional assessment of Paget's disease-causing mutations in sequestosome-1 (SQSTM1)

      ba0001pp493
    • BMP-9 induces the calcification of vascular smooth muscle cells

      ba0001pp494
    • Long-term effects of symptomatic vs intensive bisphosphonate therapy for Paget's disease of bone: the PRISM-EZ study

      ba0001pp495
    • The miR-221/222 family regulates vascular smooth muscle cell calcification

      ba0001pp496
    • A frameshift mutation in receptor activator of NF-[kappa]B reveals a potential ligand-independent mechanism for NF-[kappa]B activation

      ba0001pp497
    • Toxic osteomyelitis of the jaw ones against the backgrounds of chronic intoxication

      ba0001pp498
    • Histological structure of the albino rats lower incisors of different ages after thymectomy

      ba0001pp499
    • IFITM5 c.[ndash]14C[ge]T mutation causes variable type V osteogenesis imperfecta phenotype and decreased COL1A1 expression but increased mineralization by cultured proband osteoblasts

      ba0001pp500
    • Abnormal type I collagen glycosylation pattern and cross-linking in a cyclophilin B KO mouse model of recessive osteogenesis imperfecta

      ba0001pp501
  • Paediatric bone disease
  • • Craniofacial consequences of high-dose zoledronic acid injections in onco-pediatric patients

      ba0001pp502
    • High dickkopf-1 levels in sera and leukocytes from children with 21-hydroxylase deficiency on chronic glucocorticoid treatment

      ba0001pp503
    • The serum levels of carboxylated and undercarboxylated osteocalcin in children with cystic fibrosis

      ba0001pp504
    • Associations between leptin, growth factors and bone turnover markers in prepubertal obese children

      ba0001pp505
    • Body composition in 3- and 4-year-old preterm and full-term infants [ndash] preliminary data

      ba0001pp506
    • Perceived activity capability in children and adolescents with osteogenesis imperfecta

      ba0001pp507
    • Comparison of the bone densitometry and anthropometric parameters between the Ukrainian, Indian and Nigerian young male students, graduated in Lugansk State Medical University

      ba0001pp508
  • Steroid hormones and receptors
  • • Prostate tumorigenesis in estrogen receptor [beta] inactivated, prostate targeted fibroblast growth factor 8B transgenic mice

      ba0001pp509
    • Glucocorticoids inhibit bone formation independent of miRNA regulation

      ba0001pp510
    • The survey perception by 85 specialist physicians of the corticosteroid adverse events

      ba0001pp511
    • Positive regulation of osteogenesis by bile acid through FXR

      ba0001pp512
    • Indole-3-carbinol and epigallocatechin-3-gallate for complex treatment of inflammatory periodontal diseases in female patients with gynecological pathologies

      ba0001pp513