Osteoporosis pathophysiology and genetics

The endocannabinoid system has important effects on bone mass and bone turnover. Mice with targeted inactivation of type 1 (CB1) and type 2 (CB2) cannabinoid receptors develop osteoporosis with increasing age raising the possibility that cannabinoid receptor agonists might protect against age-related bone loss. Since cannabis is the most widely used illegal drug and its main psychotropic component -Δ9-tetrahydrocannabinol (THC)- is an agonist at CB1 and CB2 receptors, we ...

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ba0001oc3.2 | Osteoporosis pathophysiology and genetics | ECTS2013

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ba0001oc3.3 | Osteoporosis pathophysiology and genetics | ECTS2013

Distinct relationships of intramuscular and subcutaneous fat with cortical bone: findings from a cross sectional study of young adult males and females

Deere Kevin , Sayers Adrian , Viljakainen Heli , Lawlor Debbie , Sattar Naveed , Kemp John , Fraser William , Tobias Jon

Introduction: Intracellular fat within muscle and visceral tissue has been suggested to adversely influence bone development.Design: We aimed to compare associations between intramuscular and subcutaneous fat and cortical bone outcomes in young adults, in cross-sectional analyses based on the Avon Longitudinal Study of Parents and Children.Method: Data were collected from a research clinic conducted at 17 years of age. Intramuscula...

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ba0001oc3.4 | Osteoporosis pathophysiology and genetics | ECTS2013

Cortical exceeds trabecular bone loss before menopause but net bone loss is modest because periosteal apposition occurs

Bjornerem Ashild , Wang Xiaofang , Ghasem-Zadeh Ali , Bui Minh , Hopper John , Zebaze Roger , Seeman Ego

Introduction: Bone mineral density decreases before menopause and is held to be due to trabecular, not cortical, bone loss. Yet neither a negative bone balance, nor accelerated remodelling occurs before 45 years of age. We hypothesized that bone loss will first appear after 45 years and will be cortical (as 80% of bone is cortical).Methods/design: Images of distal tibia acquired using high-resolution peripheral quantitative computed tomography (Scanco Me...

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ba0001oc3.5 | Osteoporosis pathophysiology and genetics | ECTS2013

Genome-wide association identifies a new susceptibility locus at 4q35 associated with clinical vertebral fractures in post-menopausal women: the GEFOS-GENOMOS consortium

Alonso N , Estrada K , Herrera L , Kabir D , Olmos J M , Sanudo C , Riancho J A , Oei L , Medina-Gomez M C , Stenkjaer L , Bjerre L , Langdahl B , Brown M A , Duncan E L , Sims M , Kaptoge S , Reeve J , Lewis J , Prince R , Reppe S , Olstad O K , Gautvik K M , Garcia-Giralt N , Nogues X , Mencej-Bedrac S , Marc J , del Pino J , Gonzalez-Sarmiento R , Wolstein O , Eisman J , Feenstra B , Melbye M , Albagha O M E , WTCCC , Davies G , Starr J , Deary I , Quintela I , Fernandez C , Carracedo A , Lucas G , Elosua R , Uitterlinden A G , Rivadeneira F , Ralston S H

Vertebral fractures (VF) defined by morphometric analysis of spine radiographs are the most common complication of osteoporosis. Those that come to medical attention, with symptoms such as back pain and kyphosis are termed clinical vertebral fractures (CVF) and account for significant morbidity and mortality. Although much progress was made in identifying loci for bone mineral density, the genetic determinants of CVF remain unclear. Here we present the initial results from a g...

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ba0001oc3.6 | Osteoporosis pathophysiology and genetics | ECTS2013

Causal metabolomic pathways to osteoporosis in elderly women

Moayyeri Alireza , Hart Deborah , Erte Idil , Mangino Massimo , Hammond Christopher , Spector Timothy

Background: Recent technological omics advances have empowered us to identify associations between genetic markers and various traits. Knowledge of serum metabolites as intermediary phenotypes can help us achieve a better understanding of the causal pathways from genes to complex diseases like osteoporosis.Methods: In the context of TwinsUK study, serum metabolomic profiles of 6055 participants were assessed using a non-targeted mass spectrom...

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Bone Abstracts

European Calcified Tissue Society Congress 2013

Oral Communications

Heavy cannabis use negatively impacts on bone density: a population based prospective study

Distinct relationships of intramuscular and subcutaneous fat with cortical bone: findings from a cross sectional study of young adult males and females

Cortical exceeds trabecular bone loss before menopause but net bone loss is modest because periosteal apposition occurs

Genome-wide association identifies a new susceptibility locus at 4q35 associated with clinical vertebral fractures in post-menopausal women: the GEFOS-GENOMOS consortium

Causal metabolomic pathways to osteoporosis in elderly women

BiosciAbstracts