ICCBH2015 Poster Presentations (1) (201 abstracts)
Osteomyelitis and septic arthritis in children: first data from the EUCLIDS network
Werner Zenz 1 , Andreas Trobisch 1 , Daniela Klobassa 1 , Alexander Binder 1 , Matthias Sperl 2 , Federico Martinon-Torres 3 , Irene Rivero 3 , Enitan D Carrol 4 , Stephane Paulus 5 , Bojang Kalifa 6 , Suzanne Anderson 6 , Luregn Schlapbach 7, , Marieke Emonts 9, , Michiel van der Flier 11 , Ronald de Groot 11 , Navin Boeddha 12 , Jethro Herberg 13 , Paul Agapow 14 , Michael Levin 13 & -on behalf of EUCLIDS consortium 15
1Department of General Pediatrics, University Clinic of Pediatrics and Adolescence Medicine, Medical University Graz, Graz, Austria; 2Department of Pediatric Orthopaedics, Medical University of Graz, Graz, Austria; 3Translational Pediatrics and Infectious Diseases Section, Pediatrics Department, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain; 4Department Clinical Infection, Microbiology and Immunology, University of Liverpool Institute of Infection and Global Health, Liverpool, UK; 5Paediatric Infectious Diseases, Alder Hey Children’s Hospital, Liverpool, UK; 6Deparment of Paediatrics, Medical Research Council Unit, Banjul, Gambia; 7University Children’s Hospital Bern, University of Bern, Bern, Switzerland; 8Paediatric Critical Care Research Group, University of Queensland, St. Lucia, Australia; 9Great North Children’s Hospital, Newcastle upon Tyne Hospitals Foundation Trust, Newcastle upon Tyne, UK; 10Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK; 11Department of Pediatric Infectious Diseases and Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmengen, The Netherlands; 12Divisions of Pediatric Infectious Diseases & Immunology, Paediatric Intensive Care University Medical Center, Erasmus MC-Sophia Children’s Hospital, Rotterdam, The Netherlands; 13Section of Paediatrics, Division of Infectious Diseases, Department of Medicine, Imperial College London, London, UK; 14Department of Genomics of Common Diseases, Imperial College London, London, UK, 15FP7, GA#279185, http://www.euclids-project.eu, UK.
Background and aims: Bone and joint infections like osteomyelitis and septic arthritis occur in ~3–12/100.000 children per year in high-income countries with predominance in males. The most common causative pathogen is Staphylococcus aureus, however, only in 50% pathogen detection succeeds. The aim of this study is to describe clinical characteristics of osteomyelitis and septic arthritis in children recruited within the EUCLIDS network (www.euclids-project.eu).
Methods: Data was collected within the European Childhood Life-threatening Infectious Disease Study, an international and interdisciplinary network with the aim to study life-threatening bacterial infections. 195 participating hospitals from 9 countries collected data from children aged between 1 month and 18 years.
Results:: 296 pro- and retrospective cases of bone and joint infections were recruited within the network between July 2012 and December 2014 (131 in UK, 46 in Austria, 39 in Switzerland, 38 in the Netherlands, 23 in Spain, and 19 in Gambia). 163 children had osteomyelitis, 104 had septic arthritis and 29 had both osteomyelitis and septic arthritis. Median age was 6 years (IQR 8.5 years), 57% children were male. In osteomyelitis most commonly the femur (30%) and tibia (27%) were affected whereas in septic arthritis it was the hip (35%) and knee (33%). The most common pathogen detected was Staphylococcus aureus (38%), however, in 39% of all cases no organism was identified.
Conclusion: The clinical characteristics of osteomyelitis and septic arthritis are still unchanged whereby in more than one third of our sample no causative organism was identified.
Disclosure: The authors declared no competing interests.
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