ICCBH2013 Poster Presentations (1) (201 abstracts)
Fasting total ghrelin levels are increased in patients with adolescent idiopathic scoliosis
Isabelle Gennero 2, , Françoise Conte-Auriol 2, , Marianne Mus 2, , Catherine Molinas-Cazals 2, , Franck Accadbled 3 , Maïthé Tauber 1, , Jérôme Sales De Gauzy 3 & Jean Pierre Salles 1,
1Endocrine and Bone Diseases Unit, Children Hospital, Toulouse University Hospital, Toulouse, France; 2INSERM UMR 1043, University of Toulouse, Toulouse, France; 3Orthopaedics Unit, Children Hospital, Toulouse University Hospital, Toulouse, France; 4Clinical Investigation Unit, Children Hospital, Toulouse University Hospital, Toulouse, France; 5Biochemistry, Institute of Biology, Toulouse University Hospital, Toulouse, France.
Objectives: Ghrelin is an orexigenic hormone produced by the stomach that reflects body weight changes and stimulates GH secretion. Recently, it has been shown to be associated with bone metabolism and eating behaviour. The underlying pathophysiology of adolescent idiopathic scoliosis (AIS) refers to possible abnormal bone development. AIS patients also frequently present with low BMI level.
Eating behavioural disorders, endocrine disorders, abnormal growth pattern and osteopenia have been well documented in AIS. However, the circulating levels of ghrelin have never been evaluated in patients with AIS.
Methods: A study was designed to investigate circulating ghrelin levels in adolescent girls with AIS and normal control subjects. Forty-nine AIS girls and 15 controls were included. Anthropometric parameters and fasting circulating total ghrelin were measured. Curve severity was evaluated in AIS girls. The relationships between ghrelin and age, body weight, height, BMI, BMI Z-score and corrected anthropometric parameters were analyzed in AIS girls and controls.
Results: A significant increase of circulating ghrelin was found in AIS girls compared with controls. Elevation of ghrelin levels remained significant when considering corrected BMI or corrected BMI Z-score. Unlike in controls, positive correlations were found between ghrelin and age in AIS girls. Indeed, a gradual increase of circulating ghrelin was observed until 13.9 years of age, while remaining stable thereafter. There was no significant difference in body weight, height, BMI or BMI Z-score between AIS and controls.
Conclusion: We observed significantly higher circulating ghrelin levels in AIS as compared to controls with a positive correlation with age. These observations suggest that ghrelin might play a role in the initiation or development of AIS and consequences on bone status.
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Bone Abstracts
ISSN 2052-1219 (online)
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